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Behavioural Intervention

Breath-Holding for Sleep Apnea (CHAIR Trial)

N/A
Waitlist Available
Research Sponsored by University of Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up continuous collection during both visits (2 hours on back-to-back days). data will be extracted during free breathing (1 minute average before each apnea) and during apneas (10 beats preceding the resumption of breathing to 1 minute after apnea end).
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to study the effects of breath-holding (apneas) on heart rate and blood pressure responses in human subjects. The researchers are interested in understanding how oxygen concentrations affect these responses and how

Who is the study for?
This trial is for 20 healthy volunteers, including 10 females, interested in participating in research about breath-holds (apneas) and their effects on heart rate and blood pressure. Participants should be able to perform apneas and breathe low oxygen levels without health risks.
What is being tested?
The study tests the consistency of heart rate and blood pressure responses during apneas across different sessions. Volunteers will undergo breath-hold exercises with hypoxia to see if these responses are repeatable within a day (repeatability) and consistent between days (reproducibility).
What are the potential side effects?
Potential side effects may include discomfort from holding one's breath, changes in heart rate or blood pressure due to hypoxia, dizziness, or lightheadedness during or after the apnea exercises.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~continuous collection during both visits (2 hours on back-to-back days). data will be extracted during free breathing (1 minute average before each apnea) and during apneas (beat-by-beat extraction from the 10 beats preceding resumption of breathing).
This trial's timeline: 3 weeks for screening, Varies for treatment, and continuous collection during both visits (2 hours on back-to-back days). data will be extracted during free breathing (1 minute average before each apnea) and during apneas (beat-by-beat extraction from the 10 beats preceding resumption of breathing). for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Heart Rate
Secondary study objectives
Apnea Duration
Blood Pressure
Cardiac Arrhythmias
+2 more
Other study objectives
End-Tidal Carbon Dioxide
End-Tidal Oxygen
Minute Ventilation

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Apnea Following Isocapnic HypoxiaExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of AlbertaLead Sponsor
921 Previous Clinical Trials
431,835 Total Patients Enrolled
~11 spots leftby Nov 2025