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Serial PRP injections for Hoarseness

N/A
Waitlist Available
Led By Michael Johns, MD
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights

Summary

This trial will test if injecting a special substance from a patient's own blood into their vocal cords can help improve voice problems caused by aging or damage. The treatment aims to use the body's natural healing abilities to repair and strengthen the vocal cords.

Eligible Conditions
  • Vocal Fold Scar
  • Presbylarynx
  • Hoarseness
  • Laryngeal Atrophy
  • Vocal Cord Atrophy
  • Presbylarynges
  • Sulcus Vocalis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Incidence of Treatment-Emergent Adverse Events as assessed by FDA/CBER Adverse Event Severity Grading Scale
Secondary study objectives
Objective Vocal Quality as assessed by experts using the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) instrument
Diagnostic Imaging
Voice-Related Quality of Life as assessed by Voice Handicap Index-10 (VHI-10) and Vocal Fatigue Index (VFI)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Serial PRP injectionsExperimental Treatment1 Intervention
This arm will receive experimental intervention of serial monthly platelet-rich plasma (PRP) injections to a unilateral vocal fold mucosa for a total of 4 injections.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Serial PRP injections
2020
N/A
~20

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
936 Previous Clinical Trials
1,613,467 Total Patients Enrolled
Michael Johns, MDPrincipal InvestigatorUniversity of Southern California
1 Previous Clinical Trials
18 Total Patients Enrolled
~3 spots leftby Sep 2025
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