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Cognitive Behavioral Therapy for Chronic Pain

N/A
Waitlist Available
Led By Magdalena Naylor, MD, PhD
Research Sponsored by University of Vermont
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At least 12 months of muscular-skeletal, non-neuropathic pain
Be older than 18 years old
Must not have
Malignancy causing or influencing chronic pain
Awaiting pain related surgical procedure
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

This trial will test whether Cognitive Behavioral Therapy (CBT) can help to change the way the brain processes pain, potentially reducing chronic pain.

Who is the study for?
This trial is for individuals who have been experiencing muscular-skeletal, non-neuropathic chronic pain for at least a year. It's not suitable for those with certain types of pain conditions like RSD, pregnant women, people over the MRI weight limit or with incompatible implants, anyone awaiting surgery related to their pain, involved in litigation about their pain, suffering from psychiatric disorders or malignancy affecting their chronic pain.
What is being tested?
The study examines if group Cognitive Behavioral Therapy (CBT) combined with a relapse prevention program called Therapeutic Interactive Voice Response (TIVR) can change how the brain processes chronic pain. Participants will also receive Pain Education and some may be assigned to a control group without TIVR.
What are the potential side effects?
Since this trial involves psychotherapy and educational interventions rather than medication, typical drug side effects are not expected. However, participants might experience emotional discomfort or distress as they explore cognitive and behavioral aspects of managing chronic pain.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have had muscle or joint pain for at least 12 months.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My cancer is causing me chronic pain.
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I am waiting for surgery to relieve my pain.
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I have had radiation or chemotherapy, or I have cancer that has spread.
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I suffer from nerve pain or RSD.
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I use opioid medication to manage my pain.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2019 Phase 4 trial • 356 Patients • NCT02511236
1%
Achillese tendon injury
1%
Suicidal ideation
100%
80%
60%
40%
20%
0%
Study treatment Arm
Group Cognitive Behavioral Therapy
General Health Education

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Therapeutic Interactive Voice ResponseExperimental Treatment1 Intervention
Four months of therapeutic interactive voice response (TIVR).
Group II: Group Cognitive Behavioral TherapyExperimental Treatment1 Intervention
Participants will undergo 11 weeks of group cognitive behavioral therapy (CBT) and a pre- and post-intervention MRI brain scan.
Group III: Pain EducationActive Control1 Intervention
Participants will receive 11 weeks of pain education and a pre- and post-intervention MRI brain scan.
Group IV: No TIVRActive Control1 Intervention
Control - no intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Group Cognitive Behavioral Therapy
2010
Completed Phase 4
~1270

Find a Location

Who is running the clinical trial?

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NIH
493 Previous Clinical Trials
1,089,310 Total Patients Enrolled
10 Trials studying Chronic Pain
779 Patients Enrolled for Chronic Pain
University of VermontLead Sponsor
274 Previous Clinical Trials
3,743,636 Total Patients Enrolled
4 Trials studying Chronic Pain
4,321 Patients Enrolled for Chronic Pain
Magdalena Naylor, MD, PhDPrincipal InvestigatorFaculty, University of Vermont College of Medicine

Media Library

Group Cognitive Behavioral Therapy Clinical Trial Eligibility Overview. Trial Name: NCT01794988 — N/A
Chronic Pain Research Study Groups: Pain Education, Therapeutic Interactive Voice Response, No TIVR, Group Cognitive Behavioral Therapy
Chronic Pain Clinical Trial 2023: Group Cognitive Behavioral Therapy Highlights & Side Effects. Trial Name: NCT01794988 — N/A
Group Cognitive Behavioral Therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT01794988 — N/A
~8 spots leftby Sep 2025
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