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Neuromodulation

rTMS for Adolescent Depression

N/A
Recruiting
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years

Summary

This trial studies if a brain stimulation therapy can help depressed teens by changing how they process emotions.

Who is the study for?
This trial is for boys and girls aged 14-21 with major depression, as defined by the DSM-5. They must have a significant level of depression despite having tried at least one antidepressant treatment, be on a stable medication regimen for 4 weeks prior to the study without changes during it, and be able to follow all study procedures.
What is being tested?
The study tests how rTMS (repetitive Transcranial Magnetic Stimulation), a non-invasive brain stimulation technique, affects emotional processing in depressed adolescents. It starts with one session followed by an open-label phase of active rTMS treatments over four weeks.
What are the potential side effects?
rTMS may cause discomfort at the site of stimulation, headache, lightheadedness or seizures in very rare cases. Most side effects are mild and temporary.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Recruitment rates
Secondary study objectives
estimating the magnitude of difference detectable in cortico-limbic activity between groups

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Active StimulationActive Control1 Intervention
15 Depressed adolescents will undergo emotional processing tasks (within and outside the fMRI scanner) after one session of active rTMS
Group II: Sham StimulationPlacebo Group1 Intervention
15 Depressed adolescents will undergo emotional processing tasks (within and outside the fMRI scanner) after one session of sham rTMS

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor
674 Previous Clinical Trials
1,565,825 Total Patients Enrolled

Media Library

rTMS (Neuromodulation) Clinical Trial Eligibility Overview. Trial Name: NCT05832294 — N/A
Recruitment Research Study Groups: Active Stimulation, Sham Stimulation
Recruitment Clinical Trial 2023: rTMS Highlights & Side Effects. Trial Name: NCT05832294 — N/A
rTMS (Neuromodulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05832294 — N/A
~1 spots leftby Jan 2025
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