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Transcranial Magnetic Stimulation

TMS for Depression (SCC-TMS Trial)

N/A
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Accompanied by at least two evidence-based augmentation therapies (Benzodiazepines do not count)
All subjects must be between 18-65 years of age
Must not have
Neurological conditions that include epilepsy, cerebrovascular disease, dementia, increased intracranial pressure, having a history of repetitive or severe head trauma, or with primary or secondary tumors in the central nervous system
Diagnosis of acute or chronic psychotic symptoms or disorders (such as schizophrenia, schizophreniform or schizoaffective disorder) in the current depressive episode
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout study completion, 6 weeks on average
Awards & highlights
No Placebo-Only Group

Summary

This trial will investigate whether it is safe to give people transcranial magnetic stimulation(TMS) at frequencies other than 10 Hz. Up to 30 people will receive TMS weekly for 6 weeks.

Who is the study for?
This trial is for adults aged 18-65 with severe Major Depressive Disorder who haven't improved after trying at least two different antidepressants and psychotherapy. Participants must be able to commit to the study schedule and visits, but can't join if they have a high seizure risk, certain neurological conditions, scalp infections, mental incapacity, or magnetic-sensitive implants near the treatment area.
What is being tested?
The study tests repetitive Transcranial Magnetic Stimulation (TMS) at non-standard frequencies to treat depression. It involves an initial assessment using EEG, determining TMS settings tailored for each person, weekly mood checks, and up to 30 TMS sessions over a maximum of six weeks.
What are the potential side effects?
Potential side effects of TMS may include discomfort at the stimulation site on the scalp, headache, lightheadedness, or seizures in rare cases. Most people tolerate it well without serious complications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am receiving two or more approved additional treatments (not including benzodiazepines).
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I am between 18 and 65 years old.
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I have tried at least 2 antidepressants without improvement.
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My condition did not improve after treatments from two different types of medication.
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I have been diagnosed with severe Major Depressive Disorder.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a neurological condition like epilepsy or severe head trauma.
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I have been diagnosed with a psychotic disorder during my current depressive episode.
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I have a metal implant or device near my head that might be affected by magnets.
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I have an infection or bad skin condition on my scalp.
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I am able to understand and consent to participate in the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~throughout study completion, 6 weeks on average
This trial's timeline: 3 weeks for screening, Varies for treatment, and throughout study completion, 6 weeks on average for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Inventory of Depressive Symptoms-Self-report scores

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: SCC-Determined TMSExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,561 Previous Clinical Trials
10,258,996 Total Patients Enrolled
106 Trials studying Depression
49,598 Patients Enrolled for Depression

Media Library

Transcranial magnetic Stimulation (Transcranial Magnetic Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT04166864 — N/A
Depression Research Study Groups: SCC-Determined TMS
Depression Clinical Trial 2023: Transcranial magnetic Stimulation Highlights & Side Effects. Trial Name: NCT04166864 — N/A
Transcranial magnetic Stimulation (Transcranial Magnetic Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04166864 — N/A
~0 spots leftby Dec 2024
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