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Physician Focus Group for Gastrointestinal Cancer (DPYD Nudges Trial)

N/A
Waitlist Available
Led By Sony Tuteja, PharmD, MS
Research Sponsored by Abramson Cancer Center at Penn Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Fluent in English
* Currently involved in the practice or policy of GI oncology/DPYD testing/FP use/Healthcare Development OR * Prescribed a FP for GI cancer diagnosis in the past six months AND Currently licensed to provide health care in Pennsylvania or New Jersey OR * Previous diagnosis of GI malignancy or family member who had GI malignancy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 minutes
Awards & highlights

Summary

5-fluorouracil and capecitabine, sometimes called 5-FU, fluoropyrimidines, or Xeloda are a type of chemotherapy. Many people have side effects from these drugs like nausea, diarrhea, or blood problems. This research study is being conducted to learn how to help increase the number of patients offered DPYD testing before taking this type of chemotherapy drugs. DPYD testing can help predict risk of side effects. Different people's bodies break down and use drugs faster or slower. Genes are the instructions that tell our bodies how to do this. The DPYD gene is one of the genes that tell your body how to use chemotherapy drugs. Some people have changes in their DPYD gene that can make their side effects from chemotherapy worse, sometimes so bad that they die. DPYD testing can tell doctors which people have these gene changes and need extra monitoring during chemotherapy. Some of the people in this study will join a focus group and read sample messages for future patients. They will discuss with the other participants how well the message does its job and anything that might make the message better. When there are no more messages, the host may ask about other information for future patients like a website or brochure. Other people in the study will read sample messages that may be sent to future patients about DPYD testing. They will select the message that they like the best and might make them ask their oncologist about testing options.

Who is the study for?
This trial is for patients with gastrointestinal cancers who are going to be treated with chemotherapy drugs like 5-FU or capecitabine. It aims to include those interested in participating in discussions on how best to communicate the importance of DPYD genetic testing, which can predict severe side effects from these drugs.
What is being tested?
The study is not testing a drug but rather different strategies for encouraging DPYD gene testing before starting chemotherapy. Participants will either join focus groups or evaluate messages designed to inform about the benefits of this genetic test.
What are the potential side effects?
Since this trial does not involve medication, there are no direct side effects from interventions being tested. However, it relates to reducing adverse reactions from chemotherapy by identifying individuals at risk through genetic testing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Developmental Nudge Feedback
Discrete Nudge Feedback

Trial Design

4Treatment groups
Experimental Treatment
Group I: Physician Focus GroupExperimental Treatment1 Intervention
To develop patient- and clinician-directed nudges that will address biases to DPYD testing. Clinicians will be engaged to provide input on developing the content and design of the nudges that address biases that impact the decision to order DPYD testing. Feedback will be elicited for nudges based on relevancy, nudge timing, and appropriateness. We will also develop/refine patient- and clinician-focused educational materials and test results based on input from our focus groups.
Group II: Physician Discrete ChoiceExperimental Treatment1 Intervention
To pilot test clinician-nudges using discrete choice experiments, we will test the degree each nudge is associated with the perceived intention to order testing (clinician). Clinicians will be shown a series of nudges, and asked to choose which of each pair is the better nudge. The location/timing of the nudge in their workflow will be presented as part of the discrete choice.
Group III: Patient Focus GroupExperimental Treatment1 Intervention
To develop patient-directed nudges that will address biases to DPYD testing. Patients will be engaged to provide input on developing the content and design of the nudges that address biases that impact the decision to order DPYD testing. Feedback will be elicited for nudge content, clarity, and perceived urgency. We will also develop/refine patient-focused educational materials and test results based on input from our focus groups.
Group IV: Patient Discrete ChoiceExperimental Treatment1 Intervention
To pilot test patient-nudges using discrete choice experiments, we will test the degree each nudge is associated with perceived likelihood to prompt discussion regarding testing. Patients will be shown a series of nudges, and asked to choose which of each pair is the better nudge.

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,789 Previous Clinical Trials
40,986,135 Total Patients Enrolled
Abramson Cancer Center at Penn MedicineLead Sponsor
398 Previous Clinical Trials
147,996 Total Patients Enrolled
Sony Tuteja, PharmD, MSPrincipal InvestigatorUniversity of Pennsylvania
3 Previous Clinical Trials
887 Total Patients Enrolled
~107 spots leftby Mar 2025