What side effects are associated with this type of intervention?

Common side effects of treatments for femoral neck fractures using nerve signal blockade techniques like the Pericapsular Nerve Group (PENG) block include temporary numbness, weakness in the affected limb, allergic reactions to the anesthetic, infection at the injection site, bleeding, and rare cases of nerve damage. Patients may also experience transient lower limb numbness and paraesthesias. These side effects are typically mild and temporary.

What prior FDA approvals exist?

The FDA has approved various regional anesthesia techniques for pain management in femoral neck fractures, including femoral nerve blocks and fascia iliaca compartment blocks (FICB). These methods involve the use of local anesthetics to block nerve signals and reduce pain perception. While the Pericapsular Nerve Group (PENG) block is a newer approach being studied, similar techniques like femoral nerve blocks have been widely used and are well-established in clinical practice for managing pain associated with femoral neck fractures.

What other types of research exist?

Promising alternatives to the Pericapsular Nerve Group (PENG) block for femoral neck fracture patients include the Fascia Iliaca Compartment Block (FICB) and the Femoral Nerve Block. Both techniques have been shown to effectively manage pain in hip fracture patients and may offer comparable or complementary benefits to the PENG block.

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PENG vs FICB Anesthesia for Hip Fracture

N/A

Recruiting

Research Sponsored by University of Virginia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from block administration until time of surgery or 24 hours if surgery performed >24 hours

Awards & highlights

Summary

This trial compares two methods of numbing the hip area in elderly patients with hip fractures. These methods aim to reduce pain and may be more effective and safer than traditional pain medications.

Who is the study for?

This trial is for emergency department patients with hip fractures, specifically femoral neck or intertrochanteric fractures. Participants must consent to the procedure and not have allergies to local anesthetics. Those with severe injuries causing instability, serious unstable medical conditions, or hemodynamic instability cannot join.

What is being tested?

The study compares two regional anesthesia techniques: PENG (Pericapsular Nerve Group) block and FICB (Fascia Iliaca Compartment Block), in terms of pain control effectiveness for hip fracture patients. The hypothesis suggests that PENG might be more effective based on prior studies.

What are the potential side effects?

Potential side effects may include discomfort at the injection site, possible nerve damage, infection risk at the injection area, bleeding complications due to needle insertion, and allergic reactions to the anesthetic used.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from block administration until time of surgery or 24 hours if surgery performed >24 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from block administration until time of surgery or 24 hours if surgery performed >24 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and from block administration until time of surgery or 24 hours if surgery performed >24 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Pain score

Secondary study objectives

Opioid use

Trial Design

2Treatment groups

Active Control

Group I: PENGActive Control1 Intervention

Patients with hip fracture randomized to receive PENG block

Group II: FICBActive Control1 Intervention

Patients with hip fracture randomized to received FICB

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Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

The Pericapsular Nerve Group (PENG) block is a regional anesthesia technique that targets the nerves supplying the hip joint to reduce pain perception by injecting local anesthetics near the nerves, thereby blocking pain signal transmission to the brain. This method is particularly beneficial for femoral neck fracture patients as it provides effective pain relief, reduces the need for systemic opioids, and minimizes the risk of opioid-related side effects such as delirium, especially in elderly patients. Similar treatments include the femoral nerve block and the Fascia Iliaca Compartment Block (FICB), which also aim to block nerve signals to alleviate pain. These regional anesthesia techniques are crucial for improving patient comfort, facilitating early mobilization, and potentially enhancing recovery outcomes.

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor

771 Previous Clinical Trials

1,284,247 Total Patients Enrolled

Media Library

FICB Clinical Trial Eligibility Overview. Trial Name: NCT05505604 — N/A

Femoral Neck Fracture Research Study Groups: PENG, FICB

Femoral Neck Fracture Clinical Trial 2023: FICB Highlights & Side Effects. Trial Name: NCT05505604 — N/A

FICB 2023 Treatment Timeline for Medical Study. Trial Name: NCT05505604 — N/A

~17 spots leftby Sep 2025

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