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Low vs High Sodium Diet for High Blood Pressure

N/A
Recruiting
Led By Srividya Kidambi, MD
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
English speaking subjects
Be older than 18 years old
Must not have
Presence of bleeding disorders
Non-English speakers
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Summary

This trial looks at how different people's bodies react to salt in order to better understand and treat salt-sensitive hypertension.

Who is the study for?
This trial is for English-speaking individuals with blood pressure levels indicating elevated BP or Stage 1 hypertension, as per the 2017 ACC/AHA guidelines. It's not suitable for those with normal or severe high blood pressure, diabetes, heart failure, liver cirrhosis, electrolyte issues, kidney disease, certain medication use (like glucocorticoids), pregnant/nursing women, bleeding disorders, heavy daily salt intake (>6000 mg/day), metallic implants presence in body including pacemakers.
What is being tested?
The study investigates how a low sodium diet versus a high sodium diet affects kidney oxygenation and metabolism in people who are sensitive to salt. This could help understand why some individuals develop high blood pressure when they consume salt and lead to better diagnostic methods and treatments.
What are the potential side effects?
While this trial involves dietary changes rather than medications that typically have side effects like drugs do; potential discomforts may include cravings or dissatisfaction with the assigned diets.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I speak English.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a bleeding disorder.
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I do not speak English.
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I have a history of kidney disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes in renal regional tissue oxygenation in response to salt intake and salt sensitivity
Secondary study objectives
Changes in renal metabolites in response to a high sodium diet among individuals who are salt-sensitive versus insensitive

Trial Design

2Treatment groups
Active Control
Group I: Low sodium dietActive Control1 Intervention
-Subjects will be randomized to start a low sodium diet (1200 mg/day) for two weeks (this will be followed by a high sodium diet - crossover design)
Group II: high sodium dietActive Control1 Intervention
-Subjects will be randomized to start a high sodium diet (4200 mg/day) for two weeks (this will be followed by a low sodium diet - crossover design)

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
620 Previous Clinical Trials
1,172,504 Total Patients Enrolled
Srividya Kidambi, MDPrincipal InvestigatorMedical College of Wisconsin
1 Previous Clinical Trials
57 Total Patients Enrolled

Media Library

high sodium diet Clinical Trial Eligibility Overview. Trial Name: NCT05369416 — N/A
High Blood Pressure Research Study Groups: Low sodium diet, high sodium diet
High Blood Pressure Clinical Trial 2023: high sodium diet Highlights & Side Effects. Trial Name: NCT05369416 — N/A
high sodium diet 2023 Treatment Timeline for Medical Study. Trial Name: NCT05369416 — N/A
~46 spots leftby Jan 2030
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