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Antioxidant

Grape Seed Extract for High Blood Pressure (GSEBP Trial)

N/A
Recruiting
Led By Britt Burton-Freeman
Research Sponsored by Clinical Nutrition Research Center, Illinois Institute of Technology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age between 40-60 years
Fasting blood glucose concentration between 100-125 mg/dL or HbA1c between 5.7-6.4%
Must not have
Major trauma or surgery within 2 months (or longer depending on event)
Diagnosis of diabetes or documented liver, kidney, cardiac, gastrointestinal, metabolic, or respiratory diseases
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Summary

This trial aims to study how Grape seed Extract (GSE) called MegaNatural BP can help in reducing the effects of inflammation and stress on blood vessels and insulin activity. Participants will take 150mg

Who is the study for?
This trial is for individuals with prediabetes and high blood pressure. Participants should be interested in testing a grape seed extract supplement to see if it can improve their heart health by reducing blood pressure and inflammation.
What is being tested?
The study tests the effects of MegaNatural BP, a specific grape seed extract (GSE), at a dose of 150mg daily against a placebo. It aims to determine whether this GSE can positively affect blood vessel function and reduce cardiometabolic risk factors.
What are the potential side effects?
Potential side effects are not specified here, but generally, supplements like GSE may cause digestive upset or allergic reactions in some people. The trial will monitor for any adverse effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 40 and 60 years old.
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My fasting blood sugar is between 100-125 mg/dL or my HbA1c is between 5.7-6.4%.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have not had major surgery or serious injury in the last 2 months.
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I have been diagnosed with diabetes or a disease affecting my liver, kidneys, heart, stomach, metabolism, or lungs.
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I am not taking any medications or supplements that could affect the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Difference in change of diastolic blood pressure
Difference in change of systolic blood pressure
Secondary study objectives
Change in GSE metabolites profiles
Change in fasting and postprandial glucose
Change in fasting and postprandial insulin
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: GSE CapsuleExperimental Treatment1 Intervention
150mg Grapeseed Extract MegaNatural BP
Group II: Placebo CapsulePlacebo Group1 Intervention
Placebo supplement in place of GSE capsule

Find a Location

Who is running the clinical trial?

Clinical Nutrition Research Center, Illinois Institute of TechnologyLead Sponsor
54 Previous Clinical Trials
2,920 Total Patients Enrolled
Britt Burton-FreemanPrincipal Investigator708-563-8276
~53 spots leftby May 2025
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