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Exercise for Type 2 Diabetes (DYNAMMO-T2DEX Trial)

N/A
Waitlist Available
Led By John Kirwan, PhD
Research Sponsored by Pennington Biomedical Research Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Type 2 Diabetes
Be between 18 and 65 years old
Must not have
Evidence of type 1 diabetes or requiring insulin therapy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial looks at the relationship between how well cells process sugar and fats, and the development of type 2 diabetes.

Who is the study for?
This trial is for adults with Type 2 Diabetes who have a Body Mass Index (BMI) between 25 and 40 kg/m², an HbA1C level below 8.5%, and lead a sedentary lifestyle. It's not open to those currently on diabetes medication or smokers.
What is being tested?
The study investigates how exercise affects the mitochondria in muscle cells of people with Type 2 Diabetes, which could influence insulin resistance and blood sugar levels, potentially leading to new treatments.
What are the potential side effects?
Since the intervention being studied is exercise, potential side effects may include typical post-exercise symptoms such as muscle soreness, fatigue, or mild discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have Type 2 Diabetes.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have type 1 diabetes or need insulin therapy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Effects of exercise on mitochondrial dynamics
Secondary study objectives
Effects of exercise on mitochondrial function
Insulin sensitivity

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: exerciseExperimental Treatment1 Intervention
12 week exercise program, 5 days/week, 60 min/day
Group II: standard of careActive Control1 Intervention
12 week standard of care recommendations
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
exercise
2014
Completed Phase 4
~1190

Find a Location

Who is running the clinical trial?

Pennington Biomedical Research CenterLead Sponsor
309 Previous Clinical Trials
180,108 Total Patients Enrolled
7 Trials studying Diabetes
1,433 Patients Enrolled for Diabetes
John Kirwan, PhDPrincipal Investigator - Pennington Biomedical Research Center
Pennington Biomedical Research Center
3 Previous Clinical Trials
356 Total Patients Enrolled

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT02977442 — N/A
Diabetes Research Study Groups: exercise, standard of care
Diabetes Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT02977442 — N/A
Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT02977442 — N/A
~3 spots leftby Nov 2025
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