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Cognitive Testing for Episodic Memory

N/A
Recruiting
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Must not have
Individuals not undergoing invasive brain monitoring for epilepsy
Individuals outside of the age range (18-50 yrs)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up outcome assessed 10 minutes after intervention
Awards & highlights

Summary

"This trial aims to study a specific part of the brain called the posterior cingulate cortex (PCC) and its role in memory. Researchers will use brain recordings and stimulation to understand how different parts

Who is the study for?
This trial is for individuals undergoing neurosurgical treatment of epilepsy who are interested in contributing to research on memory. It focuses on how the posterior cingulate cortex (PCC) affects decisions based on episodic memory, like recognizing if you've seen a picture before.
What is being tested?
The study involves cognitive testing using intracranial recordings and stimulation during routine clinical monitoring. Researchers aim to understand the PCC's role in executive processes supporting memory retrieval and decision-making.
What are the potential side effects?
Since this study uses non-invasive cognitive tests and routine clinical procedures, side effects are minimal but may include discomfort from brain activity monitoring equipment used during epilepsy treatment.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am not having invasive brain monitoring for epilepsy.
Select...
I am not between the ages of 18 and 50.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~outcome assessed 10 minutes after intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and outcome assessed 10 minutes after intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes in high-frequency electrophysiological brain response
Episodic/Executive behavioral task performance accuracy
Episodic/Executive behavioral task performance speed

Trial Design

3Treatment groups
Experimental Treatment
Group I: Experiment 3 - episodic decision taskExperimental Treatment1 Intervention
All enrolled participants will be asked to perform experiment 3, which is a cognitive task involving memory-based decisions between two options (pictures of people). For each decision, the two pictures will differ in memory strength and reward (e.g., familiar picture for 10 points vs. unfamiliar picture 50 points). Memory strength for each picture will be defined by how many times the picture was previously shown (e.g., 2 vs. 10 presentations) prior to performing the memory decision task. Participants will perform this computer-based task while electrical brain activity is recorded from the posterior cingulate cortex, hippocampus and prefrontal cortex. This task takes 15 minutes to complete.
Group II: Experiment 2 - executive decision taskExperimental Treatment1 Intervention
All enrolled participants will be asked to perform experiment 2, which is a cognitive task involving reward-based decisions between two options. For each decision, the two options will differ in their risk and reward (e.g., 100% chance of 10 points vs. 30% chance of 50 points). Participants will perform this computer-based task while electrical brain activity is recorded from the posterior cingulate cortex, hippocampus and prefrontal cortex. This task takes 15 minutes to complete.
Group III: Experiment 1 - episodic / executive switchExperimental Treatment1 Intervention
All enrolled participants will be asked to perform experiment 1, which is a cognitive task involving the switch between performing episodic memory decisions (e.g., "did you eat fruit yesterday?") and executive decisions (e.g. "...does 5+3+8 = 17?"). Participants will perform this computer-based task while electrical brain activity is recorded from the posterior cingulate cortex, hippocampus and prefrontal cortex. This task takes 18 minutes to complete.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive testing
2018
N/A
~450

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Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,053 Previous Clinical Trials
43,012,997 Total Patients Enrolled
~77 spots leftby Mar 2027
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