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Interval Exercise for COPD and Sleep Apnea

N/A
Recruiting
Led By Madalina Macrea, MD PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must not have
CAD, as defined by history of CABG, prior positive stress test for ischemia, infarction or angina
Orthopedic problems as defined by joint pain limiting ambulation
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Summary

This trial is studying an exercise strategy to help reduce functional decline in veterans with both chronic obstructive pulmonary disease and obstructive sleep apnea.

Who is the study for?
This trial is for veterans with Overlap Syndrome, which means they have both COPD and OSA. They must show cognitive function with a MoCA score over 20. Those who already do structured exercise, need daytime oxygen, have recent heart issues or hospitalization, orthopedic problems limiting walking, or a high fall risk cannot join.
What is being tested?
The study aims to develop an exercise program specifically for veterans with Overlap Syndrome to prevent early functional decline. It will measure the impact of interval exercise on participation in life situations, physical activity levels, and cardiovascular health.
What are the potential side effects?
While not explicitly stated in the provided information, typical side effects from starting an exercise regimen may include muscle soreness, fatigue, shortness of breath especially if participants have pre-existing lung conditions.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a history of heart issues like bypass surgery or heart attack.
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I have joint pain that makes it hard for me to walk.
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I have fallen more than twice in the last month.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Concentration of Serum hs-CRP (mg/dL)
Number of Daily Steps
Scale number on Epworth Sleepiness Scale

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ExerciseExperimental Treatment1 Intervention
The Experimental Design is a randomized trial of Moderate intensity interval training (5-minute intervals at 50% VO2peak 3 times weekly for 12 weeks) in Veterans with COPD and OSA compared with standard of care controls
Group II: Usual CareActive Control1 Intervention
Participants in the control group will be instructed to maintain their routine activity level for 12 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise
2016
Completed Phase 1
~820

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,647 Previous Clinical Trials
3,360,042 Total Patients Enrolled
Madalina Macrea, MD PhDPrincipal InvestigatorSalem VA Medical Center, Salem, VA

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05254431 — N/A
Chronic Obstructive Pulmonary Disease Research Study Groups: Usual Care, Exercise
Chronic Obstructive Pulmonary Disease Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT05254431 — N/A
Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05254431 — N/A
~10 spots leftby Apr 2026
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