Popular Trials
Procedure
Subcision for Acne Scars
This trial is testing whether doing a minor surgical procedure called subcision can improve rolling acne scars. Subcision involves using a needle to cut through tough bands under the skin that cause scarring. The goal is to see if this method makes the skin look smoother compared to no treatment.
Procedure
Non-Abilative Laser treatment for Epidermal Thickening
The condition to be studied is post-surgical scarring following primary total knee replacement, specifically whether fractional non-ablative laser therapy can be used to significantly decrease the morbidity of scarring.
Subcision + Suction for Acne Scars
This trial is testing whether using a suction device along with regular acne scar treatments helps improve the scars more than using the regular treatment alone. It targets people with acne scars and aims to see if suction can make the treatment work better by enhancing healing and cleaning.
Procedure
Pulmonary Vein Antrum Isolation for Atrial Fibrillation
This study aims to examine the long-term success rate of catheter ablation in non-paroxysmal atrial fibrillation patients using different ablation strategies such as : (i) pulmonary vein antrum isolation (PVAI) + isolation of left atrial posterior wall, (ii) PVAI plus scar homogenization, (iii) PVAI plus isolation of posterior wall plus ablation of non-PV triggers \[ PVAI: Pulmonary Vein Antrum Isolation Non-PV triggers: Triggers arising from sites other than pulmonary veins\]
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Trials for Scarring Patients
Behavioural Intervention
Scar Treatments for Post-Cesarean Section Pain
This trial is comparing two methods to reduce post-surgical pain related to a Cesarean section. One method is scar infiltration with Lidocaine and the other is scar deactivation with acupuncture.
Neurotoxin
Botulinum Toxin for Scarring
This trial will test whether botulinum toxin type A can reduce the appearance of scars when injected into the wound at the time of surgery. The mechanism of action will be investigated by measuring micro RNA profiles at two different points in the healing process.
PDL + Fractional Photothermolysis for Scarring
This trial tests two types of lasers to improve the look of scars after surgery. It targets patients with post-surgical scars to see if these lasers can make their scars less noticeable. One laser reduces redness, while the other helps smooth out the skin.
Procedure
SutureSafe for Scarring
The purpose of this study is to evaluate the effect SutureSafe dressings have on reducing scarring from an incision following an elective abdominoplasty (tummy tuck) procedure. The scar will be evaluated using subjective clinical assessment criteria. Each participant in the study will serve as a control and experiential study, since have of the incision will be treated with the gold standard of care and the other half with SutureSafe dressings.
Trials for Hypertrophic Scar Patients
Neurotoxin
Botulinum Toxin for Scarring
This trial will test whether botulinum toxin type A can reduce the appearance of scars when injected into the wound at the time of surgery. The mechanism of action will be investigated by measuring micro RNA profiles at two different points in the healing process.
RNAi
RXI-109 for Hypertrophic Scar
This trial is testing RXI-109, a treatment to reduce thick, raised scars after surgery. It targets patients who have had surgery to improve an existing scar. The treatment works by preventing the body from making too much scar tissue.
Silicone Taping for Abdominal Scars
This trial is testing if silicone tape can make scars look better after breast reconstruction surgery. Patients will use the tape on part of their surgical scar. The study will check the scars over time to see if the tape helps. Silicone materials, including tapes and implants, have been widely used in breast reconstruction surgeries to improve outcomes and patient satisfaction.
Antifibrotic
FS2 for Scar
This trial will study the safety and effectiveness of a new ointment for managing scars after surgery. The ointment contains an antifibrogenic compound that has shown promise in preliminary studies. There are no known safety concerns with the ointment.
Phase 3 Trials
Neurotoxin
Botulinum Toxin for Scarring
This trial will test whether botulinum toxin type A can reduce the appearance of scars when injected into the wound at the time of surgery. The mechanism of action will be investigated by measuring micro RNA profiles at two different points in the healing process.
5-Fluorouracil Active Treatment Arm for Drooping Eyebrows
This trial uses 5-Fluorouracil injections to improve healing and reduce scarring after eyebrow surgery. It targets patients who have had surgery to correct drooping eyebrows. The medicine works by helping the skin heal better and reducing the formation of thick scars. 5-Fluorouracil (5-FU) has been used effectively for the treatment of hypertrophic scars and to manage excess scar tissue in various surgical contexts.
Gene Therapy
Gene Therapy for Ornithine Transcarbamylase Deficiency
This trial is testing DTX301, a treatment designed to help people with late-onset OTC deficiency, a condition that makes it hard for their bodies to process certain proteins. The treatment aims to improve the function of an enzyme that helps manage ammonia levels in the blood. Participants will be monitored for several years, with some continuing in a follow-up program for additional time.
Injectable Gel
Injectable Gel for Acne Scars
This trial is testing a new gel called ELAPR002f to help fill in and smooth out indented acne scars on the face. It targets adults with noticeable acne scars who haven't had success with other treatments. The gel works by filling in the scarred areas to make the skin look smoother. Participants will receive multiple treatments and be monitored for an extended period.
siRNA
Fazirsiran for Alpha-1 Antitrypsin Deficiency
This trial is testing fazirsiran, a drug that may reduce liver scarring and improve liver health, in patients with liver fibrosis. The drug works by decreasing harmful proteins and reducing inflammation in the liver.
Neurotoxin
Botulinum Toxin for Scarring
This trial will test whether a new medication can reduce scarring compared to using no medication. The study will use two biopsy sites on each person, so that each person serves as their own control. The study hypothesis is that the new medication will lead to less scarring.
Trials With No Placebo
Neodyne Device for Scar Improvement in Breast Reconstruction
This trial is testing a special device called the Neodyne embrace to see if it can make scars look better after breast reconstruction surgery. It focuses on women who have had this surgery using tissue from their abdomen. The device works by reducing skin tension around the scar, which helps it heal more nicely.
Monoclonal Antibodies
Dupilumab for Keloids
This trial investigates whether dupilumab, an anti-inflammatory medication, can help patients with keloids. Keloids are excessive scar tissue growths that current treatments often fail to address effectively. By blocking proteins that cause inflammation, dupilumab may reduce keloid size and improve symptoms.
Behavioural Intervention
Scar Treatments for Post-Cesarean Section Pain
This trial is comparing two methods to reduce post-surgical pain related to a Cesarean section. One method is scar infiltration with Lidocaine and the other is scar deactivation with acupuncture.
Laser Therapy
Laser Therapy for Burn Scars
This trial is testing whether or not laser therapy can help improve the appearance of burn scars. So far, there is evidence that it might be helpful, but more research is needed to know for sure. The laser therapy is expensive, so the researchers want to know if it's worth it before recommending it to patients.
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Frequently Asked Questions
Introduction to scar
What are the top hospitals conducting scar research?
When it comes to advancing the treatment of scars, several top hospitals are making significant strides in research and clinical trials. In Detroit, Henry Ford Health System leads the way with three ongoing scar trials and a total of three completed studies since their first recorded trial in 2007. Moving down south to Gainesville, Florida, the University of Florida is actively conducting three scar trials but does not have any previous completed studies in this area. Similarly, at University Hospitals Cleveland Medical Center in Cleveland, researchers are currently engaged in three active scar trials without any recorded past investigations.
Heading over to Chicago's Northwestern University Feinberg School of Medicine, Department of Dermatology plays a crucial role as well. They currently have three active scar trials and have made progress with two previously conducted studies since initiating their first trial also back in 2007. Finally, Massachusetts General Hospital adds its name to this list by having joined the efforts with three ongoing scar clinical tests while contributing through completing two previous inquiries; they embarked on investigating scarring cases most recently from only six years ago-2015.
These hospitals collectively showcase their commitment towards finding innovative solutions for individuals burdened by scars. By dedicating resources and expertise to these specialized clinical trials across different locations nationwide, medical professionals strive to improve patients' quality of life while paving new paths for effective treatments and potential breakthroughs.
Which are the best cities for scar clinical trials?
In the realm of scar clinical trials, several cities emerge as top contenders for cutting-edge research. Boston, Massachusetts leads the pack with 10 ongoing studies exploring treatments like Dupilumab, Fazirsiran, and Eplerenone. Chicago, Illinois closely follows with 9 active trials investigating Cabazitaxel, Fractional Photothermolysis, and Pulsed Dye Laser therapies. New york City also boasts 9 active trials focusing on innovative treatments such as Sofwave and PicoWay technology. While Miami, Florida offers 6 active trials centered around OLX10010 and laser-based interventions. Lastly, Phoenix, Arizona showcases 4 ongoing studies evaluating treatment options like Cabazitaxel and Descartes-08. These cities provide individuals seeking scar treatment opportunities to participate in groundbreaking clinical trials that hold promise for improved outcomes.
Which are the top treatments for scar being explored in clinical trials?
Clinical trials for scar treatments are currently exploring several promising options. The Neodyne Device, introduced in 2022, is being tested in one active trial dedicated to scars. Another potential treatment is the Er:YAG laser, which has two all-time scar trials and is currently being investigated in one ongoing trial. Additionally, the Botox Injectable Product shows promise as a scar treatment option with one active trial and its first listing in 2020. These innovative approaches bring hope for improved outcomes and enhanced quality of life for individuals dealing with scarring issues.
What are the most recent clinical trials for scar?
Recent clinical trials offer promising prospects for scar treatment, with potential breakthroughs on the horizon. In a Phase 1 trial, autologous adipose derived SVF has shown encouraging results in scar management. Another Phase 1 trial explored the effectiveness of cyclophosphamide and fludarabine combined with radiation as a therapeutic approach for scars. Additionally, Fazirsiran is undergoing Phase 3 testing to evaluate its efficacy in scar treatment. Dupilumab underwent Phase 2 trials and shows promise as another potential option for managing scars effectively. Lastly, DTX301 completed its Phase 3 trial stage which assessed its effectiveness in treating scarring conditions. These recent advancements hold the key to improving outcomes for individuals dealing with scars.
What scar clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the field of scar treatment. These studies focused on developing novel approaches to address scarring and promote better healing outcomes. While details may vary, these trials collectively demonstrate a commitment to advancing therapeutic options for scars. The results from these recent investigations provide hope for individuals seeking effective solutions to minimize or improve the appearance of scars and enhance their quality of life.