← Back to Search

Medications + WeightWatchers for Obesity (Meds WOW-WW Trial)

N/A

Recruiting

Led By Michelle Cardel, PhD, RD

Research Sponsored by Michelle Cardel, PhD, MS, RD

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

BMI of >30 or BMI of >27 with one or more weight related medically qualifying condition (hypertension, dyslipidemia, sleep apnea, cardiovascular disease)

Be older than 18 years old

Must not have

Currently taking naltrexone

Engagement with vomiting or laxative use within the last 28 days with the aim of controlling their shape or weight

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 12 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial is looking at whether adults who are overweight or obese lose more weight by taking weight management medications alone or with behavioral and lifestyle support. They will measure the percentage of body weight lost after 12

Who is the study for?

This trial is for adults with obesity (BMI >30) or overweight (BMI >27) with related health issues like high blood pressure. They must be starting a weight management medication plan approved by WW Clinic, without recent significant weight loss, no history of eating disorders, surgical obesity treatment, seizures, glaucoma, or certain chronic diseases.

What is being tested?

The study tests if taking weight management medications alone is as effective as combining them with behavioral and lifestyle support from WeightWatchers. The main goal is to see how much body weight participants lose after 12 weeks.

What are the potential side effects?

Possible side effects may include those associated with the medications Bupropion/Naltrexone or Liraglutide such as nausea, headaches, dizziness. Behavioral support might also bring psychological stress due to lifestyle changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My BMI is over 30, or it's over 27 with a condition like high blood pressure or heart disease.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am currently taking naltrexone.

Select...

I have used vomiting or laxatives to control my weight in the last month.

Select...

I have a history of glaucoma.

Select...

I have a history of chronic kidney disease.

Select...

I am currently taking bupropion.

Select...

I have a history of seizures.

Select...

I have lost more than 11 pounds in the last 3 months.

Select...

I have had surgery for obesity.

Select...

I am not pregnant, breastfeeding, nor planning to become pregnant and I use effective birth control.

Select...

My blood pressure is not well-controlled.

Select...

I am currently using opioid medication.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Percent body weight lost at 12 weeks

Secondary study objectives

Body Appreciation

Change in body weight (in kg or pounds) at 12 weeks

Dietary Intake

+8 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Meds plus WWExperimental Treatment1 Intervention

Participants in this group receive behavioral or lifestyle support from WW Clinic alongside their medications. The medications are not part of the intervention (it is part of the eligibility criteria).

Group II: Meds aloneActive Control1 Intervention

Participants in this group do not receive behavioral or lifestyle support alongside their medications. The medications are not part of the intervention (it is part of the eligibility criteria).

0 / 12Eligibility criteria met