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Novelty facilitated extinction for Anxiety Disorders
N/A
Waitlist Available
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up only on the day of the experiment
Awards & highlights
Summary
The purpose of this study is to use functional magnetic resonance imaging to investigate how the human brain learns to form associations between neutral and emotional stimuli. The study is based on the basic principles of Pavlovian conditioning. When someone learns that a neutral stimulus (such as the sound of a bell) predicts an unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the properties of an emotional stimulus. The investigators are interested in the neural processes involved in this learning in people with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).
Eligible Conditions
- Anxiety Disorders
- Post-Traumatic Stress Disorder
- Social Anxiety Disorder
- Panic Disorder
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ only on the day of the experiment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~only on the day of the experiment
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Changes in functional magnetic resonance imaging (fMRI)-BOLD (blood-oxygen-level dependent) signal in sensory, prefrontal, and limbic regions during a study on the neurobiology of Pavlovian fear conditioning in humans
Secondary study objectives
Skin conductance responses evoked during a Pavlovian fear conditioning task in humans as an index of physiological arousal.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Standard extinctionExperimental Treatment1 Intervention
The shock is omitted during standard extinction
Group II: Novelty facilitated extinctionExperimental Treatment1 Intervention
Behavioral intervention. After Pavlovian fear conditioning, the shock is omitted and replaced by a novel, surprising, and neutral auditory tone.
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Who is running the clinical trial?
University of Texas at AustinLead Sponsor
370 Previous Clinical Trials
83,146 Total Patients Enrolled
17 Trials studying Anxiety Disorders
2,378 Patients Enrolled for Anxiety Disorders
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