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Prebiotic

Oligofructose-enriched inulin (p-inulin) for Chronic Kidney Disease (TarGut Trial)

N/A
Waitlist Available
Led By Jennifer J. Gassman, Ph.D.
Research Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up collected weekly for 28 weeks
Awards & highlights
No Placebo-Only Group

Summary

The purpose of this Phase 1, 3-period crossover with repeated measures feasibility study is to characterize the gut microbiome of individuals with chronic kidney disease, and to explore effects of p-inulin on the gut microbiome. The nature of the study will provide information about the feasibility of stool sample collection for future multicenter studies of the gut microbiome.

Eligible Conditions
  • Chronic Kidney Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~collected weekly for 28 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and collected weekly for 28 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Adherence to p inulin prescription
Microbial composition of stool
Secondary study objectives
Allantoin
Betaine
Choline
+18 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Oligofructose-enriched inulin (p-inulin)Experimental Treatment2 Interventions
Participants are on no treatment for 8 weeks, then the pre-biotic p-inulin for 12 weeks, then no treatment for 8 weeks. Inulin is derived from chicory root fiber. The dose is 16 grams of p-inulin powder per day.

Find a Location

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Lead Sponsor
2,439 Previous Clinical Trials
4,324,806 Total Patients Enrolled
George Washington UniversityOTHER
252 Previous Clinical Trials
461,132 Total Patients Enrolled
University of PennsylvaniaOTHER
2,073 Previous Clinical Trials
42,714,340 Total Patients Enrolled
~2 spots leftby Nov 2025
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