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Psychosocial Interventions for Schizophrenia

N/A
Recruiting
Research Sponsored by Beth Israel Deaconess Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 to 65
DSM-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measurement at 0, 6, 12 months
Awards & highlights

Summary

This trialwill measure how smell affects mental health treatment for people with schizophrenia, to better tailor interventions and help improve outcomes.

Who is the study for?
This trial is for individuals aged 18 to 65 with a diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder. It's not suitable for those with severe substance use disorders, intellectual disabilities, or organic brain syndromes as per DSM-5 criteria.
What is being tested?
The study aims to see if a person's sense of smell can predict who will benefit from social skills training and cognitive enhancement therapy in treating schizophrenia.
What are the potential side effects?
Since the interventions are psychosocial rather than medical treatments like drugs or surgery, they may include discomfort during therapy sessions but do not have physical side effects typical of medications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 65 years old.
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I have been diagnosed with schizophrenia or a related disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measurement at 0, 6, 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and measurement at 0, 6, 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Heinrich Quality of Life Scale
Change in Social Adjustment Scale II
Change in Social Skills Performance Assessment rating scale
Secondary study objectives
Change in Managing Emotions subscale of the Meyer-Salovey-Caruso Emotional Intelligence Test (MSCEIT)
Change in NIH Toolbox® for Assessment of Neurological and Behavioral Function (NIH Toolbox)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Enhancement TherapyExperimental Treatment1 Intervention
CET is a comprehensive manualized cognitive remediation program designed to maximize gains in social functioning by integrating computer-based training to enhance neurocognition with group-based exercises to improve social cognition.
Group II: Social Skills TrainingActive Control1 Intervention
The HOPES social rehabilitation program uses the principles of SST (modeling, role playing, positive and corrective feedback, homework assignments, in vivo skills practice), designed to improve both psychosocial functioning and preventive health.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Enhancement Therapy
2012
N/A
~160

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,869 Previous Clinical Trials
2,777,420 Total Patients Enrolled
253 Trials studying Schizophrenia
89,808 Patients Enrolled for Schizophrenia
Beth Israel Deaconess Medical CenterLead Sponsor
848 Previous Clinical Trials
12,929,988 Total Patients Enrolled
22 Trials studying Schizophrenia
2,155 Patients Enrolled for Schizophrenia

Media Library

Cognitive Enhancement Therapy Clinical Trial Eligibility Overview. Trial Name: NCT05282186 — N/A
Schizophrenia Research Study Groups: Cognitive Enhancement Therapy, Social Skills Training
Schizophrenia Clinical Trial 2023: Cognitive Enhancement Therapy Highlights & Side Effects. Trial Name: NCT05282186 — N/A
Cognitive Enhancement Therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT05282186 — N/A
~20 spots leftby Feb 2025
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