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Brain Stimulation

Repetitive Transcranial Magnetic Stimulation (rTMS) for Schizophrenia

N/A
Waitlist Available
Led By Michael Avissar, MD, PhD
Research Sponsored by Columbia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 4 weeks
Awards & highlights

Summary

This trial is testing a treatment that uses magnetic pulses to change brain activity on patients with schizophrenia who hear voices and don't respond well to other treatments. The goal is to see if this method can reduce these hallucinations by adjusting brain activity in specific areas. This non-invasive treatment has been studied for many years as a potential solution for auditory hallucinations in schizophrenia, showing promising but variable results.

Eligible Conditions
  • Schizophrenia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 4 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Total Number of Treatment Emergent Adverse Events
Total Number of rTMS Sessions Completed
Secondary study objectives
Change in Auditory Hallucination Rating Scale (AHRS)
Change in Cardiff Anomalous Perceptions Scale (CAPS)
Change in Positive and Negative Syndrome Scale (PANSS)- General Psychopathology
+8 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Individualized magnetic resonance imaging (MRI) guided rTMSExperimental Treatment1 Intervention
Participants will receive a type of TMS called repetitive TMS (rTMS) wherein the magnetic pulses delivered will be close together in a rapid sequence. They will receive a 20-min once-daily rTMS sessions over a period of 2 weeks (weekends off), and therefore accrue a total of 10 rTMS stimulation sessions. The rTMS parameters that will be used are a frequency of 1 Hz (1 pulse per second) at an intensity of 90% of the motor threshold (MT). Therefore, the investigators will deliver 1200 continuous pulses per session/day which adds up to 12,000 pulses in total for the whole treatment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation (rTMS)
2019
Completed Phase 2
~780

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,869 Previous Clinical Trials
2,777,525 Total Patients Enrolled
253 Trials studying Schizophrenia
89,913 Patients Enrolled for Schizophrenia
Columbia UniversityLead Sponsor
1,471 Previous Clinical Trials
2,536,339 Total Patients Enrolled
24 Trials studying Schizophrenia
3,315 Patients Enrolled for Schizophrenia
Michael Avissar, MD, PhDPrincipal InvestigatorNew York State Psychiatric Institute
1 Previous Clinical Trials
3 Total Patients Enrolled
1 Trials studying Schizophrenia
3 Patients Enrolled for Schizophrenia
~4 spots leftby Sep 2025
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