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Obese for Obstructive Sleep Apnea

N/A
Waitlist Available
Led By Indra Narang, BMEDSci, MBBCH, MD
Research Sponsored by The Hospital for Sick Children
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 1-4
Awards & highlights

Summary

This trial is testing heated humidified high-flow air (HHF) as a treatment for patients with Obstructive Sleep Apnea (OSA). HHF delivers warm, moist air through the nose to help keep the airways open and reduce breathing interruptions during sleep. Heated humidification has been shown to reduce nasal symptoms and improve initial use in patients with obstructive sleep apnea (OSA).

Eligible Conditions
  • Obstructive Sleep Apnea
  • Obesity
  • Central Sleep Apnea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 1-4
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 1-4 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in apnea-hypopnea index (AHI) with HHF compared to the change in AHI with CPAP
Secondary study objectives
Comparative COMFORT scales with HHF and CPAP.

Trial Design

2Treatment groups
Active Control
Group I: ObeseActive Control1 Intervention
Obese subjects ages 10-18 years with OSA will be recruited from sleep clinic. As per standard clinic care, once a subject is diagnosed with OSA on a PSG they are reviewed in sleep clinic to discuss CPAP therapy. Families will be approached to participate in this study during the subject's regularly scheduled clinical visit. Obese subjects meeting eligibility criteria will be recruited from the sleep clinic. The patients agreeing to CPAP therapy will be invited to take part in the study.
Group II: CMCActive Control1 Intervention
As per current standard clinical care, CMC diagnosed with moderate to severe OSA following a clinically indicated baseline PSG who have had a previous adenotonsillectomy or who are not considered candidates for surgery are reviewed in sleep clinic to discuss the prescription of CPAP for OSA. CMC subjects' meeting eligibility criteria will be recruited from the sleep clinic. The patients agreeing to CPAP therapy will be invited to take part in this study.

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Who is running the clinical trial?

The Hospital for Sick ChildrenLead Sponsor
704 Previous Clinical Trials
6,956,857 Total Patients Enrolled
Indra Narang, BMEDSci, MBBCH, MDPrincipal InvestigatorThe Hospital for Sick Children
1 Previous Clinical Trials
102 Total Patients Enrolled
~3 spots leftby Sep 2025
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