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Fear Conditioning Interventions for PTSD

N/A

Recruiting

Led By Mohammed Milad

Research Sponsored by NYU Langone Health

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

a. Diagnosis of current PTSD (as determined by CAPS, and primary diagnosis of PTSD as determined by SCID assessment of comorbidity)

18 - 70 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up experimental day 1, experimental day 2

Awards & highlights

No Placebo-Only Group

Summary

This trial is measuring how the brain learns to avoid certain stimuli or situations, and how fear extinction and cost can change that.

Who is the study for?

This trial is for adults aged 18-70 with current PTSD, diagnosed through specific assessments (CAPS and SCID). It's also open to trauma-exposed healthy controls without any history of psychiatric disorders or PTSD. Participants must be willing to undergo experiments involving avoidance of stimuli.

What is being tested?

The study tests how people with PTSD learn to avoid things that scare them. It involves measuring brain responses and feelings during tasks like paying to avoid shocks, learning about fear, avoiding conditioned stimuli, and overcoming learned fears.

What are the potential side effects?

Since this is a psychological study involving fear and avoidance behaviors, participants may experience increased anxiety or stress during the tasks. However, there are no physical side effects as it does not involve medication or invasive procedures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with PTSD as my primary condition.

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I am between 18 and 70 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ experimental day 1, experimental day 2

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~experimental day 1, experimental day 2

This trial's timeline: 3 weeks for screening, Varies for treatment, and experimental day 1, experimental day 2 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Comparison of Skin Conductance Response (SCR) of PTSD participants and Trauma-Exposed Healthy Controls

Post-Traumatic Stress Disorder

Secondary study objectives

Change in Anxiety

Change in Emotional Stress tolerance

Change in shock expectancy

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Trauma-Exposed Healthy Controls (TEHC)Experimental Treatment4 Interventions

After the initial screening / baseline assessment visit, trauma-exposed healthy participants will undergo two Experimental Visits, which included participation in an emotional learning paradigm and an fMRI scan over the course of two consecutive days. Participants will be asked to look at pictures on a computer screen to measure physiological response physiological response (skin conductance response) and brain responses using a functional Magnetic Resonance Imaging (fMRI) machine. These two visits will be scheduled within a month from the baseline assessment visit.

Group II: PTSD groupExperimental Treatment4 Interventions

After the initial screening / baseline assessment visit, Post Traumatic Stress Disorder participants will undergo two Experimental Visits, which included participation in an emotional learning paradigm and an fMRI scan over the course of two consecutive days. Participants will be asked to look at pictures on a computer screen to measure physiological response physiological response (skin conductance response) and brain responses using a functional Magnetic Resonance Imaging (fMRI) machine. These two visits will be scheduled within a month from the baseline assessment visit.

0 / 2Eligibility criteria met