Aerobic Exercise for Parkinson's Disease (GEARS Trial)

Phase 2 & 3

Recruiting

Research Sponsored by Jay Alberts

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Hoehn and Yahr stage I-III

Adult with a diagnosis of PD by a physician or physician extender

Must not have

Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke)

Current cardiac arrhythmia

Timeline

Screening 3 weeks

Treatment Varies

Follow Up enrollment on and off medications, 6 months post-enrollment, and 12 months post-enrollment

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study how genetics and exercise can impact the progression of Parkinson's Disease (PD). They will recruit 200 PD patients from Cleveland and Salt Lake City to participate in a community-based exercise

Who is the study for?

Adults with Parkinson's Disease (PD) stages I-III who can safely use a stationary bike, have reliable transport to the exercise facility, and own a smartphone for monitoring activity. They must be on stable PD medication.

What is being tested?

The trial is testing if high-intensity cycling 3 times a week at community sites can slow down PD progression. It also examines how genetics might influence this effect. Participants will cycle for one year and undergo genetic testing.

What are the potential side effects?

While specific side effects are not listed, high-intensity exercise may cause fatigue, muscle soreness or strain, increased heart rate during activity, and potential falls or injuries related to using the stationary bike.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My Parkinson's disease is in the early to mid-stage.

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I have been diagnosed with Parkinson's disease by a healthcare professional.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a neurological condition that is not Parkinson's disease.

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I have a heart rhythm problem.

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I have deep brain stimulation or focused ultrasound for Parkinson's.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ enrollment on and off medications, 6 months post-enrollment, and 12 months post-enrollment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~enrollment on and off medications, 6 months post-enrollment, and 12 months post-enrollment

This trial's timeline: 3 weeks for screening, Varies for treatment, and enrollment on and off medications, 6 months post-enrollment, and 12 months post-enrollment for reporting.