Popular Trials
Calcium Channel Blocker and Angiotensin II Receptor Blocker Combination
Amlodipine and Olmesartan +1 More for High Blood Pressure
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels. These cells help keep blood vessels healthy and blood pressure normal.
Herbal Supplement
American Ginseng (Panax quinquefolius L.) +1 More for Type 2 Diabetes
The study is a 2 phase double blind randomized placebo control trial. The objective is to asses the metabolic and therapeutic effects of American Ginseng (Panax quinquefolius L.) extract and Korean Red Ginseng (steamed Panax C.A. Meyer) extract in the management of type 2 diabetes in a 12 week period. One Hundred and twenty subjects with type 2 diabetes (hyperglycemia key inclusion criteria: HbAlc≥6.5% - ≤ 8.1% ) will participate in the study (36 men and 36 post-menopausal women).
Protein Supplement
Whey +2 More for Mild Cognitive Impairment
Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic pathway. Since serotonin plays a prominent role in neuropsychological functions such as anxiety, mood and memory, the enhanced sensitivity of the serotonergic pathway in aging can probably explain the fact that elderly are more vulnerable to develop cognitive deficits and depressive symptoms. Serotonin synthesis in brain is regulated by its precursor tryptophan (TRP). Because tryptophan is an essential amino acid, modifying the availability of tryptophan through dietary intake, can directly influence central serotonin metabolism and consequently affective and cognitive processes. The aim of this study is to test the hypothesis that an acute intake of whey protein with high levels of TRP such as alpha-lactalbumin can stabilize the metabolism of serotonin and subsequently enhance metabolic and cognitive functions in healthy older adults. The acute effects of this dietary protein will be investigated in subjects with mild cognitive impairment (MCI), or dementia, compared to control subjects in order to examine whether healthy older subject with MCI benefit more from the intake of alpha-lactalbumin and/or whey. The investigators will investigate if this meal can optimize serotonin metabolism by elevating plasma TRP levels and plasma TRP appearance and enhance splanchnic TRP extraction. In addition, the effects on mood and cognitive functions will be examined.
Behavioral Intervention
Lifestyle Promotion Intervention for Obesity
This trial is testing a lifestyle intervention that uses wearable sensors to gather data on a person's physical activity. The intervention is designed to promote physical activity and reduce sedentary time to improve cardiometabolic risk factors such as obesity, hypertension, and disorders in glucose regulation.
Popular Filters
Trials for Metabolic Syndrome Patients
1 for Obstructive Sleep Apnea
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome. The investigators hypothesize that the sleep fragmentation and intermittent sleep hypoxia which occur in OSAH patients promote oxidative stress and inflammation which in turn lead to insulin resistance, dyslipidemia, abnormal vascular reactivity and other processes which are consistent with the metabolic syndrome.
Behavioural Intervention
Weight Loss for Obesity and Metabolic Syndrome
This trial is investigating how fat is stored in organs, and why this impacts some people's health more than others. The findings could lead to better treatments for diabetes and cardiovascular disease.
Dietary Supplement
Fat Feeding for Metabolic Syndrome
Among 10 premenopausal women with Metabolic Syndrome: Specific Aim 1: Compare the effects of acute fat feeding on flow mediated dilation (FMD) as measured by brachial artery reactivity among three fat challenges (saturated fat vs. monounsaturated fat (MUFA) vs. polyunsaturated fat (PUFA)at 4 hours post feeding. Hypothesis Saturated fat feeding will impair FMD but MUFA and PUFA feeding will not. Specific Aim 2: Compare the effects of acute feeding on vascular inflammation as measured by VCAM and sICAM among three fat challenges at 3 1/2 hours post feeding. Hypothesis: Saturated fat feeding will increase vascular inflammation but MUFA and PUFA will not.
Insulin
Humulin +2 More for Metabolic Syndrome
The purpose of this study is to determine if restoring normal metabolic function in patients with type 1 or type 2 diabetes can improve the impact of the consequences of diabetic complications on the overall health and quality of life for diabetic patients.Patients are treated once per week with intensive bolus intravenous insulin delivery mimicking normal insulin secretions in a non diabetic individual. Baseline and periodic diagnostic tests are performed and questionnaires completed to evaluate and monitor progress and outcomes.
Corticosteroid
Testosterone for Insulin Resistance
This trial is testing different treatments involving testosterone to see if they can help build muscle, reduce fat, and improve how the body handles sugar. Researchers believe that testosterone will improve body composition and insulin sensitivity, with different effects depending on the additional treatments used. Testosterone therapy has been shown to increase muscle mass, reduce fat, and improve insulin sensitivity in various studies.
Behavioural Intervention
Omega-3 Fatty Acids for Metabolic Syndrome
The purpose of this study is to determine the effects of omega-3 fatty acids in the form of fish oil supplementation (approximately 2 grams per day) on the carotid intima-media (CIMT)progression (primary objective) and 2)(Secondary objective) lipid markers such as LDL, apo-B, and LDL buoyancy, on inflammatory burden as measured by CRP, on oxidative stress as measured by urinary isoprostanes, urine microalbumin/creatinine, and serum adiponectin a fat derived hormone in subjects with metabolic syndrome.
Trials for MetS Patients
1 for Obstructive Sleep Apnea
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome. The investigators hypothesize that the sleep fragmentation and intermittent sleep hypoxia which occur in OSAH patients promote oxidative stress and inflammation which in turn lead to insulin resistance, dyslipidemia, abnormal vascular reactivity and other processes which are consistent with the metabolic syndrome.
Behavioural Intervention
Weight Loss for Obesity and Metabolic Syndrome
This trial is investigating how fat is stored in organs, and why this impacts some people's health more than others. The findings could lead to better treatments for diabetes and cardiovascular disease.
Dietary Supplement
Fat Feeding for Metabolic Syndrome
Among 10 premenopausal women with Metabolic Syndrome: Specific Aim 1: Compare the effects of acute fat feeding on flow mediated dilation (FMD) as measured by brachial artery reactivity among three fat challenges (saturated fat vs. monounsaturated fat (MUFA) vs. polyunsaturated fat (PUFA)at 4 hours post feeding. Hypothesis Saturated fat feeding will impair FMD but MUFA and PUFA feeding will not. Specific Aim 2: Compare the effects of acute feeding on vascular inflammation as measured by VCAM and sICAM among three fat challenges at 3 1/2 hours post feeding. Hypothesis: Saturated fat feeding will increase vascular inflammation but MUFA and PUFA will not.
Insulin
Humulin +2 More for Metabolic Syndrome
The purpose of this study is to determine if restoring normal metabolic function in patients with type 1 or type 2 diabetes can improve the impact of the consequences of diabetic complications on the overall health and quality of life for diabetic patients.Patients are treated once per week with intensive bolus intravenous insulin delivery mimicking normal insulin secretions in a non diabetic individual. Baseline and periodic diagnostic tests are performed and questionnaires completed to evaluate and monitor progress and outcomes.
Behavioural Intervention
Omega-3 Fatty Acids for Metabolic Syndrome
The purpose of this study is to determine the effects of omega-3 fatty acids in the form of fish oil supplementation (approximately 2 grams per day) on the carotid intima-media (CIMT)progression (primary objective) and 2)(Secondary objective) lipid markers such as LDL, apo-B, and LDL buoyancy, on inflammatory burden as measured by CRP, on oxidative stress as measured by urinary isoprostanes, urine microalbumin/creatinine, and serum adiponectin a fat derived hormone in subjects with metabolic syndrome.
Behavioural Intervention
Health Coaching for Metabolic Syndrome
Antipsychotic medications frequently cause metabolic side-effects, such as abdominal obesity, high blood pressure, cholesterol abnormalities, and blood sugar dysregulation, all of which can lead to what is known as the Metabolic Syndrome and serious long-term cardiovascular health problems. Therefore, it is important that metabolic issues be addressed as part of a holistic approach to the mental health treatment of these patients. As with the general population, improving metabolic health involves lifestyle changes - i.e., addressing daily habits regarding eating, physical exercise, stress and sleep management, and lifestyle habits such as smoking. However, there is growing recognition in the medical field that education is not enough for people to create meaningful and sustained lifestyle change. The emerging field of Integrative Health Coaching addresses this issue and provides a clinical framework for helping people successfully develop and achieve personalized lifestyle goals. The investigators have therefore decided to investigate whether health coaching techniques may have benefit in addressing metabolic health issues in people with psychosis disorders. The intent is to complement usual psychiatric and medical care, and also promote patient engagement in managing one's overall health. This study will investigate whether Integrative Health Coaching is a useful clinical tool to facilitate healthy lifestyle behaviour and thereby improve metabolic health in people with psychosis disorders.
Trials With No Placebo
Procedure
Bone Marrow Aspirate for Osteonecrosis
This trial seeks to find the best treatment for a musculoskeletal disease (ONFH) that causes pain, loss of function and may require hip replacement. It compares different joint-preserving treatments to see which works best.
Monoclonal Antibodies
Denosumab for Fibrous Dysplasia
This trial is testing denosumab, a drug that helps strengthen bones, in adults with fibrous dysplasia, a condition where bones grow abnormally. Denosumab works by stopping the cells that break down bone tissue, aiming to reduce bone pain and improve bone strength.
View More Related Trials
Frequently Asked Questions
Introduction to osteopenia
What are the top hospitals conducting osteopenia research?
When it comes to clinical trials focused on osteopenia, a condition characterized by low bone mass and an increased risk of fractures, several hospitals are leading the way. In Saint Louis, Washington University School of Medicine is currently conducting four active trials for osteopenia. Although they don't have any past trials specifically dedicated to this condition, their commitment to ongoing research highlights their dedication in understanding and treating osteopenia. Meanwhile, the University of Alabama at Birmingham has three active trials and two previously conducted studies on record since 2012, demonstrating their investment in finding innovative approaches for managing this condition.
Notably, the prestigious Mayo Clinic located in Rochester recently initiated its first osteopenia trial in 2020 but already has two ongoing trials highlighting their eagerness to contribute new insights into this field. Similarly committed to advancing our understanding of osteopenia is the University of Missouri-Columbia with two active clinical trials; however, they haven't conducted any previous investigations on this particular topic.
It's also worth mentioning that the National Institutes of Health Clinical Center situated in Bethesda holds an impressive track record with four completed studies focused on osteopenia since recording its first trial back in 2004. Currently engaged in two active clinical trials for this condition as well, their expertise positions them as a valuable resource for individuals seeking cutting-edge advancements regarding osteopenia management.
These hospitals collectively represent medical centers at various stages along the journey towards unlocking new knowledge about osteopenia prevention and treatment options. Their endeavors underscore how each research study contributes significantly to our ever-growing understanding of this complex disease—a stepping stone toward improving lives affected by weak bones and fractures.
Which are the best cities for osteopenia clinical trials?
For individuals seeking clinical trials related to osteopenia, several cities have emerged as notable hubs for research and development. Toronto in Ontario stands out with 10 ongoing trials exploring treatments like Metformin, Healthy Volunteers, and Chemoradiotherapy with Integrated Boost Dose. Atlanta in Georgia follows closely behind with 6 active studies focusing on interventions such as Dulaglutide Injection and Magnetic Resonance Spectroscopic Imaging. Additionally, Birmingham in Alabama and New york City both offer promising opportunities for participation in osteopenia clinical trials, each hosting 5 ongoing studies that investigate various treatments ranging from PET imaging to virtual reality exergaming. Lastly, New Brunswick in New jersey completes this list of top cities for osteopenia clinical trials with its own set of diverse studies examining factors like metabolic activity of HR+/Her2- breast cancer and tailored lighting intervention. These cities provide valuable access to cutting-edge research efforts aimed at uncovering innovative approaches towards managing osteopenia and improving patient outcomes.
Which are the top treatments for osteopenia being explored in clinical trials?
In the realm of osteopenia, clinical trials are exploring various treatments to combat this condition. One treatment at the forefront is exercise, which shows promising results in two active trials dedicated to osteopenia. Since its first listing in 2001, exercise has been subject to two all-time clinical trials focused on this bone health issue. These studies shed light on the potential benefits that physical activity can bring for individuals with osteopenia, offering a non-pharmacological approach worth considering.
What are the most recent clinical trials for osteopenia?
Exciting developments in osteopenia research have brought forth several recent clinical trials that hold promise for improved treatment options. One such trial explores the potential benefits of a fasting mimicking diet, aiming to determine its efficacy in managing osteopenia. Another study focuses on an intensive lifestyle intervention combined with tirzepatide, seeking to assess their combined impact on this condition. Additionally, vericiguat is being investigated for its potential role in treating osteopenia, while virtual reality exergaming and decitabine are also being explored as novel interventions. These ongoing trials offer hope for advancing our understanding and management of osteopenia moving forward.
What osteopenia clinical trials were recently completed?
Recently completed clinical trials have shed light on innovative approaches in the realm of osteopenia treatment. In December 2019, Roswell Park Cancer Institute concluded a trial investigating the efficacy of Denosumab in addressing this condition. Another notable study, sponsored by Masonic Cancer Center at the University of Minnesota, explored the use of Calcium and vitamin d and was completed in February 2015. These trials hold promise for advancing our understanding and management of osteopenia, providing potential avenues for improved care for individuals affected by this bone disorder.