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Pregnenolone 175mg for Social Isolation

Phase 2
Waitlist Available
Led By Stephanie Cacioppo, PhD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights
All Individual Drugs Already Approved

Summary

This trial is testing whether pregnenolone, a natural hormone, can help young adults who feel socially isolated and are very alert to social threats. Participants will receive either pregnenolone or another substance, and researchers will study how it affects their brain and behavior. Pregnenolone has been studied for its potential neuroprotective effects and its role in maintaining steroidal balance.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
EEG Results
Secondary study objectives
Eye Movement Tracking

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

4Treatment groups
Active Control
Placebo Group
Group I: Pregnenolone 175mgActive Control1 Intervention
- Single dose of 175mg
Group II: Pregnenolone 400mgActive Control1 Intervention
- Single dose of 400mg
Group III: Matched healthy controlsActive Control1 Intervention
- No intervention
Group IV: PlaceboPlacebo Group1 Intervention
- Single dose of placebo

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,052 Previous Clinical Trials
759,005 Total Patients Enrolled
Stephanie Cacioppo, PhDPrincipal InvestigatorUniversity of Chicago
1 Previous Clinical Trials
57 Total Patients Enrolled
~4 spots leftby Nov 2025
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