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Normal Exercise Group for Chronic Kidney Disease

N/A
Waitlist Available
Led By Charmaine Lok, MD, FRCPC, MSC
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 9 and week 11
Awards & highlights
No Placebo-Only Group

Summary

The purpose of this research study is to determine whether two different types of forearm exercise, performed before fistula creation surgery, can improve surgery success and fistula maturation.

Eligible Conditions
  • Chronic Kidney Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 9 and week 11
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 9 and week 11 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Late dialysis suitability failure
Secondary study objectives
Change of intra-access flow and vascular diameters at predetermined distances from the fistula anastomosis; arterial stiffness and endothelial function on a randomly determined sub sample of patients.
Fistula maturation
Plasma cGMP (cyclic guanosine monophosphate) and NO (nitric oxide) levels

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Normal Exercise GroupExperimental Treatment1 Intervention
Group 1 (Normal Exercise Group): progressive handgrip exercise Group 2 (Restricted Blood Flow Exercise Group): progressive handgrip exercise with controlled tourniquet
Group II: Control GroupActive Control1 Intervention
The control group will receive routine vascular access pre-op teaching and care.

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,520 Previous Clinical Trials
503,034 Total Patients Enrolled
Charmaine Lok, MD, FRCPC, MSCPrincipal InvestigatorUniversity Health Network, Toronto
David Cherney, MDPrincipal InvestigatorUniversity Health Network, Toronto
~19 spots leftby Nov 2025
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