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Behavioural Intervention

rTMS for Autism

N/A
Recruiting
Research Sponsored by Centre for Addiction and Mental Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
ASD or control participants aged between 18 and 40 years old
ASD or control participants with no prior history of seizure
Must not have
ASD or control participants with significantly debilitating medical or neurologic illness
ASD participants taking benzodiazepines or anticonvulsants currently
Timeline
Screening 3 weeks
Treatment Varies
Follow Up plasticity in the motor cortex will be evaluated at baseline, immediately after rtms, and 1 and 4 weeks after the last rtms session.
Awards & highlights

Summary

This trial aims to test if excessive brain flexibility in autistic adults causes motor function difficulties and if using a specific treatment called rTMS can improve motor function by reducing this flexibility.

Who is the study for?
This trial is for adults with autism who have difficulties with motor functions. Participants should be able to give informed consent and follow the study procedures. Specific details about inclusion or exclusion criteria are not provided, but typically these would outline health conditions or medications that might disqualify someone from participating.
What is being tested?
The study is examining if using repetitive Transcranial Magnetic Stimulation (rTMS) on the motor cortex can improve motor function in autistic adults by reducing hyperplasticity. There's a comparison between active rTMS and sham (placebo-like) treatment.
What are the potential side effects?
Common side effects of rTMS may include discomfort at the stimulation site, headache, lightheadedness, or seizures; however, seizures are rare. The specific side effects for this trial haven't been detailed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 40 years old.
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I have never had a seizure.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a serious medical or neurological condition along with ASD.
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I am currently taking benzodiazepines or anticonvulsants for ASD.
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I have autism or am a control participant and I am claustrophobic.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~plasticity in the motor cortex will be evaluated at baseline, immediately after rtms, and 1 and 4 weeks after the last rtms session.
This trial's timeline: 3 weeks for screening, Varies for treatment, and plasticity in the motor cortex will be evaluated at baseline, immediately after rtms, and 1 and 4 weeks after the last rtms session. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes in motor cortical plasticity using motor evoked potentials (MEPs) in autistic adults following rTMS.
Changes in motor function in autistic adults following rTMS.
Secondary study objectives
Changes in motor cortical plasticity using cortical evoked activity (CEA) in autistic adults following rTMS.
Changes in the adaptive daily living skills in autistic adults following rTMS.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Active rTMSActive Control1 Intervention
Autistic adults receiving active rTMS to the motor cortex.
Group II: Sham rTMSPlacebo Group1 Intervention
Autistic adults receiving sham rTMS to the motor cortex.

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Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor
366 Previous Clinical Trials
82,186 Total Patients Enrolled
~100 spots leftby Apr 2029
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