What side effects are associated with this type of intervention?

High-Intensity Interval Training (HIIT) for metabolic diseases can lead to musculoskeletal injuries, increased cardiovascular risk in those with pre-existing heart conditions, and overtraining-related fatigue. Lifestyle interventions like diet and exercise may cause nutritional deficiencies or injuries if not managed well. Medications such as metformin often result in gastrointestinal issues, and weight-loss surgeries can lead to complications like infections or nutrient malabsorption.

What prior FDA approvals exist?

FDA-approved treatments for metabolic diseases that align with the benefits of High-Intensity Interval Training (HIIT) include medications for diabetes, obesity, and cardiovascular health. For diabetes, drugs like metformin, GLP-1 receptor agonists (e.g., liraglutide), and SGLT2 inhibitors (e.g., empagliflozin) are approved to regulate blood glucose levels. For obesity, medications such as orlistat and phentermine-topiramate are used to aid weight loss and improve lipid metabolism. Cardiovascular health is often managed with statins (e.g., atorvastatin) to enhance lipid profiles and reduce cardiovascular risk. These treatments collectively aim to improve metabolic health, similar to the effects achieved through HIIT.

What other types of research exist?

Promising alternatives to HIIT for metabolic disease patients include: 1) Moderate-Intensity Continuous Training (MICT), which involves sustained moderate exercise and has been shown to improve cardiovascular health and metabolic parameters. 2) Resistance Training, which can enhance muscle strength, improve insulin sensitivity, and support lipid metabolism. 3) Combined Aerobic and Resistance Training, which offers comprehensive benefits by improving both cardiovascular fitness and muscle strength. 4) Low-Impact Aerobic Activities such as swimming, cycling, and walking, which are effective for improving cardiovascular health and can be tailored to individual fitness levels. 5) Tai Chi and Yoga, which have shown benefits in improving physical function, reducing stress, and enhancing overall metabolic health.

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Behavioural Intervention

HIIT for Obesity

N/A

Recruiting

Led By Joon Young Kim, Ph.D

Research Sponsored by Syracuse University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Awards & highlights

Summary

This trial tests different HIIT routines to see how they improve heart and metabolic health in young adults with obesity. Participants will do short, intense sprints followed by rest. The goal is to find the best routine to help this group improve their health.

Who is the study for?

This trial is for young adults aged 18 to 25 with obesity, defined as having a BMI of 30 or higher. It's not suitable for individuals who don't meet the age and BMI criteria.

What is being tested?

The study tests three different high-intensity interval training (HIIT) programs against no exercise in improving heart health and metabolism in obese young adults. Participants will be randomly placed into one of four groups, including a control group, to assess changes before, after intervention, and post two weeks without training.

What are the potential side effects?

While specific side effects are not listed for HIIT, common ones may include muscle soreness, fatigue, and an increased risk of injury if exercises are performed incorrectly.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Body mass index

Carotid-femoral Pulse Wave Velocity (cPWV)

Diastolic blood pressure

+13 more

Trial Design

4Treatment groups

Experimental Treatment

Group I: ControlExperimental Treatment1 Intervention

Control group

Group II: 5s HIITExperimental Treatment1 Intervention

5s HIIT group will perform one bout of sprint running for 5-seconds followed by 25-second, resting of total 40 repetition.

Group III: 20s HIITExperimental Treatment1 Intervention

20s HIIT group will perform one bout of sprint running for 20-seconds followed by 100-second, resting of total 10 repetition.

Group IV: 10s HIITExperimental Treatment1 Intervention

10s HIIT group will perform one bout of sprint running for 10-seconds followed by 50-second, resting of total 20 repetition.

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

High-Intensity Interval Training (HIIT) is a common treatment for metabolic diseases that involves short bursts of intense exercise followed by rest or low-intensity periods. This approach improves cardiovascular fitness by increasing heart rate and oxygen consumption, which strengthens the heart and enhances circulation. It also boosts lipid metabolism by promoting the breakdown of fats for energy, thereby reducing body fat and improving lipid profiles. Additionally, HIIT helps regulate blood glucose levels by increasing insulin sensitivity and glucose uptake in muscles. These mechanisms are crucial for managing metabolic diseases as they target poor cardiovascular health, dyslipidemia, and impaired glucose metabolism, which are key aspects of these conditions.

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Who is running the clinical trial?

Syracuse UniversityLead Sponsor

49 Previous Clinical Trials

117,652 Total Patients Enrolled

Joon Young Kim, Ph.DPrincipal InvestigatorSyracuse University, Departments of Exercise Science

Media Library

HIIT (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05838950 — N/A

Metabolic Diseases Research Study Groups: 5s HIIT, Control, 10s HIIT, 20s HIIT

Metabolic Diseases Clinical Trial 2023: HIIT Highlights & Side Effects. Trial Name: NCT05838950 — N/A

HIIT (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05838950 — N/A

~23 spots leftby Sep 2025

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