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Behavioural Intervention

rTMS for Depression and Substance Use Disorder

N/A
Recruiting
Led By Manish Jha, M.B.B.S
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be aged 18-65 years, inclusive
Self-report stimulant use (cocaine, methamphetamine, or prescription stimulants) at least 10 days in the 30-day period prior to consent
Must not have
Have a documented history of brain lesion(s) and/or tumor(s)
Have a documented history of unprovoked seizure (lifetime) or any seizure in the past 6 months
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Summary

This trial is testing if a specific type of brain stimulation can help people with depression and stimulant use disorder, such as methamphetamine or cocaine addiction.

Who is the study for?
This trial is for individuals who are struggling with both depression and stimulant use disorder, which includes problems with drugs like methamphetamine or cocaine. Participants should be suitable candidates for the rTMS treatment.
What is being tested?
The study is testing an accelerated course of repetitive transcranial magnetic stimulation (rTMS), a non-invasive procedure that uses magnetic fields to stimulate nerve cells in the brain, on people with depression and stimulant abuse issues.
What are the potential side effects?
Common side effects of rTMS include headaches, scalp discomfort at the site of stimulation, tingling or spasms of facial muscles, lightheadedness, and rare risk of seizure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 65 years old.
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I have used stimulants like cocaine or meth at least 10 days in the last month.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a documented history of brain lesions or tumors.
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I have had a seizure without a known cause in my lifetime or any seizure in the last 6 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Feasibility of an accelerated course of repetitive Transcranial Magnetic Stimulation (rTMS).
Secondary study objectives
Attainment of response of rTMS intervention on stimulant use assessed by Urine Drug Screens.
Changes in frequency of self-reported stimulant use based on Timeline Followback (TLFB).
Changes in self-reported symptoms of depression during the 3-week treatment phase.
+5 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: rTMS InterventionExperimental Treatment1 Intervention
Eligible participants who are enrolled will receive an accelerated course of repetitive Transcranial Magnetic Stimulation.

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,072 Previous Clinical Trials
1,056,222 Total Patients Enrolled
46 Trials studying Depression
19,361 Patients Enrolled for Depression
Manish Jha, M.B.B.SPrincipal InvestigatorUT Southwestern Medical Center
~27 spots leftby Jun 2027
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