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Genetic Test
Genetic Testing for Acute Coronary Syndrome (ACCURATE Trial)
N/A
Recruiting
Led By Liam Brunham, MD PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Admitted to an acute cardiac unit with either a ST elevation myocardial infarction (STEMI) or a non-ST elevation myocardial infarction (NSTEMI)
Maximum lipid level at the time of admission or during the prior 1 year of: LDL level ≥4 mmol/L (154 mg/dL) if not on a statin, LDL-C level ≥2.5 mmol/L (96 mg/dL) if on a statin prior to presentation, Non-HDL-C ≥4.6 mmol/L (177 mg/dL) if LDL-C not available
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights
No Placebo-Only Group
Summary
This trial will test whether genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and improve patient care and outcomes.
Who is the study for?
This trial is for people under 60 who've been admitted to a cardiac unit with a heart attack (STEMI or NSTEMI) and have high cholesterol levels. It's not open to those already diagnosed with Familial Hypercholesterolemia or on certain lipid treatments.
What is being tested?
The ACCURATE study tests if genetic testing for Familial Hypercholesterolemia in patients hospitalized for acute coronary syndrome can help diagnose this condition and influence their treatment and health outcomes.
What are the potential side effects?
Since the intervention involves genetic testing, there are no direct physical side effects. However, receiving genetic information may have psychological impacts or affect insurance status.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I was admitted for a heart attack.
Select...
My cholesterol levels have been high in the past year.
Select...
I am younger than 60 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 1 year
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Secondary study objectives
Proportion of patients who achieve guideline recommended lipid targets in the first year after ACS
Other study objectives
Rate of recurrent cardiovascular event in the first year after ACS
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Active-testingExperimental Treatment1 Intervention
Those admitted between 6-18 months of the study meeting the inclusion criteria. Saliva samples will be collected for DNA testing.
Group II: ObservationActive Control1 Intervention
Those admitted in the first 6 months of the study that meet the inclusion criteria. Patients will be treated according to the normal standard of care for acute coronary syndrome.
Find a Location
Who is running the clinical trial?
Genome British ColumbiaIndustry Sponsor
12 Previous Clinical Trials
222,992 Total Patients Enrolled
Vancouver Coastal Health Research InstituteOTHER
26 Previous Clinical Trials
4,940 Total Patients Enrolled
University of British ColumbiaLead Sponsor
1,466 Previous Clinical Trials
2,485,211 Total Patients Enrolled
4 Trials studying Acute Coronary Syndrome
1,103 Patients Enrolled for Acute Coronary Syndrome
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I was admitted for a heart attack.My cholesterol levels have been high in the past year.I am younger than 60 years old.
Research Study Groups:
This trial has the following groups:- Group 1: Active-testing
- Group 2: Observation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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