PET/MR Imaging for Pulmonary Hypertension

N/A

Recruiting

Led By Patrick Veit-Haibach, MD

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Intention to treat with radio(chemo)therapy with incidental cardiac irradiation of at least 25Gy.

Biopsy or otherwise clinically proven thoracic malignant mass which is intended to be treated with radio(chemo)therapy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 4 weeks prior to radiotherapy, and at 6-10 weeks after completion of radiotherapy

Awards & highlights

All Individual Drugs Already Approved

No Placebo-Only Group

Summary

This trial will help to improve the understanding of the pathophysiology of RT-induced cardiopulmonary dysfunction and to develop new biomarkers for early diagnosis and risk stratification.

Who is the study for?

This trial is for adults over 18 with a diagnosed thoracic cancer intended to be treated with radiotherapy that also affects the heart. They must consent to PET/MR imaging, blood tests, and not be pregnant if of child-bearing age.

What is being tested?

The study is testing how well PET/MR imaging combined with blood analysis can predict heart and lung problems after radiotherapy in patients at risk of developing pulmonary hypertension (high blood pressure in lungs).

What are the potential side effects?

While the trial itself may not have direct side effects, potential risks include discomfort from the PET/MR procedure and reactions related to contrast agents used during imaging.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am planning to undergo radiation therapy that will affect my heart.

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My chest tumor will be treated with radiation or chemo.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 4 weeks prior to radiotherapy, and at 6-10 weeks after completion of radiotherapy

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 4 weeks prior to radiotherapy, and at 6-10 weeks after completion of radiotherapy

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 4 weeks prior to radiotherapy, and at 6-10 weeks after completion of radiotherapy for reporting.