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Behavioural Intervention

Brief Exposure Therapy for PTSD (PTSD Trial)

N/A

Recruiting

Led By Bradley M Peterson, MD

Research Sponsored by Children's Hospital Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patient Population: Males and females ages 18-50

Healthy Population: Males and Females, ages 18-50

Must not have

Patient Population: Current Bipolar I Disorder

Patient Population: Neurological or serious medical conditions (e.g., stroke, epilepsy/ seizure disorder, cancer, Lupus, HIV+)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up days 3-7

Awards & highlights

No Placebo-Only Group

Summary

This trial is trying to develop a new treatment for combat veterans with PTSD. They want to know how exposure to combat-related images affects the brain and how participants feel about it. They will compare veterans with

Who is the study for?

This trial is for U.S. combat veterans who have PTSD. Participants will be exposed to combat-related images and must be able to undergo an fMRI scan. The study aims to include those directly affected by traumatic stress disorders, specifically from their military service.

What is being tested?

The trial tests a new behavioral treatment involving very brief exposure to combat images compared with visible exposure, assessing its effects on brain activity and subjective fear ratings in participants with PTSD versus healthy controls.

What are the potential side effects?

Since this is a psychological study involving viewing images, side effects may include temporary increases in stress or anxiety levels due to the exposure of potentially triggering content.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 50 years old.

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I am between 18 and 50 years old and healthy.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been diagnosed with Bipolar I Disorder.

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I have a serious condition like stroke, epilepsy, cancer, Lupus, or HIV.

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I have never been diagnosed with PTSD, Tourette's, bipolar disorder, substance dependence, an eating disorder, autism, a psychotic disorder, or acute stress disorder.

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I have received treatment for a mental health issue within the last 2 years.

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I do not have any serious medical conditions like stroke, epilepsy, cancer, Lupus, or HIV.

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I have experienced a traumatic brain injury.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ days 3-7

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~days 3-7

This trial's timeline: 3 weeks for screening, Varies for treatment, and days 3-7 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Mean Activation of Frontostriatal and Prefrontal Brain Regions to combat stimuli in PTSD

Secondary study objectives

Fear induced by exposure to combat stimuli in PTSD in healthy participants as measured by fear scale

Fear induced by exposure to combat stimuli in PTSD in veteran group as measured by fear scale

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Image Exposure ArmExperimental Treatment1 Intervention

This within-subjects design study will have all participants view three types of exposure during fMRI scanning: VBE to combat images, VBE to masked everyday scenes (control), and conscious visible exposure to the same images (control).

0 / 8Eligibility criteria met